Clips randomly need re-render?

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Hi-
I'm working with some sequences in FCP7 and sometimes, when I make a small tweak to something as simple as an audio track, suddenly several (random) clips in the sequence will require re-rendering of video - stuff I didn't come close to touching. This is painfully frustrating. Has anyone run into this before? Am I missing something?
Thanks
Chris
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Replay

Let's start at the beginning.
What codec does your footage use?
Does your Easy Setup and Sequence Setting match that codec?
Is the footage codec even one of the options listed in Easy Setup?
Where is the footage located on your computer?
What location are render files being saved to?